Sigma chi unl11/30/2023 On the other hand, miR-9 functions as a tumor inhibitor suppressing cell proliferation and invasive ability through the SDF-1/CXCR4 pathway in epithelial ovarian cancer ( 6). MiR-9 as a tumor promoter promotes the metastasis and invasion of non-small cell lung cancer (NSCLC) cells by inhibiting the expression of E-cadherin ( 4, 5). Interests of miR-9 have been grown with the aim of using it as a diagnostic and prognostic marker for tumors ( 1– 3). In the past few decades, miRNAs have been widely studied as important molecules in tumor progression, among which, the abnormal expression of miR-9 can be found in many malignancies. MicroRNAs (miRNA) are a class of small non-coding RNAs and usually regulate the expression of target functional proteins through the interaction with 3′ untranslated regions (3′-UTRs) of mRNA, thus regulating the physiological and pathological processes. In the past decade, the prognosis and treatment for GBM have not improved significantly, but there have been important gains in our understanding on genetic alterations associated with gliomagenesis, and the gene targeting therapy might be promising for glioblastoma ( 1, 2). However, it is still a challenge to completely cure due to the strong invasive and proliferative nature of GBM. With the development of modern medical technology, it is possible to remove the tumor through surgical resection followed by chemoradiation. Glioblastoma (GBM) is one of the most malignant tumors in adult central nervous system. The results of this study suggest a novel regulatory mechanism that miR-9-5p can inhibit glioma cells proliferation by downregulating FOXP2. Furthermore, we found that FOXP2 was the target protein of miR-9-5p in luciferase assay. In this study, we demonstrated that high expression of miR-9-5p and low expression of forkhead box P2 (FOXP2) were related with better outcome in patients with GBM, and down regulated FOXP2 expression was able to inhibit glioma cells proliferation by cell cycle arrest. The abnormal expression of miRNAs and its target proteins play a crucial role in the development of glioblastoma. Glioblastoma (GBM) is the most malignant tumor in the central nervous system and the treatment is still unsatisfactory because the mechanism of the disease remains unclear.
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |